Choosing the right formula for a colicky newborn can be overwhelming, with options promising relief but varying widely in ingredients and effectiveness. Enfamil A.R. stands out as the best overall pick for its clinically proven ability to reduce spit-up and reflux within a week. For parents seeking quick relief, Enfamil NeuroPro Gentlease offers easy digestion with smaller proteins, while Good Start | Dr. Brown’s Gentle Pro excels for sensitive tummies thanks to probiotics and allergen-free ingredients. The main tradeoffs involve balancing cost, ingredient sensitivity, and how quickly the formula works. Continue reading for a full breakdown of these options to find the best fit for your baby’s unique needs.
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Key Takeaways
- The most effective formulas combine gentle digestion with proven reflux and fussiness reduction.
- Formulas with added probiotics tend to support better gut health in colicky babies.
- The best options balance efficacy with minimal allergen content for sensitive infants.
- Quick-acting formulas are often more expensive but can provide faster relief.
- Choosing between ready-to-feed and powder depends on convenience versus cost considerations.
| formula for colic newborn | Size | Type | Prebiotics |
|---|---|---|---|
| Enfamil A.R. Infant Formula | 19.5 Oz | Powder | — |
| Enfamil NeuroPro Gentlease Rea | 2 fl oz bottles (6 count) | Ready-to-feed | PDX & GOS |
| Good Start | Dr. Brown’s Gentl | 32 oz | Powder | — |
| Enfamil NeuroPro Gentlease for | 27.4 oz | Powder | HuMO6, 2′-FL |
| Enfamil Optimum Gentlease Baby | 19.5 Oz | Powder | — |
| Good Start | Dr. Brown’s Sooth | 12 ounces | — | — |
| Similac 360 Total Care Infant | 20.6 oz | Powder | 5 HMO prebiotics |
| Similac 360 Total Care Sensiti | 2 fl oz per bottle | — | 5 HMO prebiotics |
| MYLICON Infants Gas Relief Dro | 1 fl oz | — | — |
| Enfamil NeuroPro Gentlease for | 30.4 oz | — | Yes |
More Details on Our Top Picks
Enfamil A.R. Infant Formula, Clinically Proven to Reduce Reflux & Spit-Up in 1 Week, with Iron, DHA for Brain Development, Probiotics to Support Digestive & Immune Health, Powder Tub, 19.5 Oz
This formula stands out for its proven ability to cut spit-up by over 50% within a week, making it ideal for parents dealing with frequent reflux. Unlike simpler formulas, its rice starch component targets reflux directly, which helps reduce discomfort and mess. It also includes DHA for brain development and probiotics for gut health, offering comprehensive support. The tradeoff is that its rice starch may slightly alter taste, which some babies might resist initially. Compared to alternatives like Enfamil NeuroPro Gentlease, this formula is more focused on reflux reduction rather than fussiness or gas. While it excels in reflux management, it may be less ideal for babies with a sensitive stomach or those needing gentle digestion support. Overall, this pick is best for babies with significant reflux or spit-up issues, providing fast and noticeable results.
Pros:- Clinically proven to reduce spit-up by over 50% in 1 week
- Includes DHA for cognitive development
- Contains probiotics for immune and digestive health
- Easy to prepare in powder form
Cons:- Rice starch may slightly alter taste, which could cause initial fussiness
- Not specifically designed for fussiness or gas relief
- Some infants may have sensitivity to rice-based formulas
Best for: Parents of infants suffering from frequent spit-up or reflux needing quick relief
Not ideal for: Parents seeking a formula primarily for fussiness, gas, or gentle digestion without reflux concerns
- Size:19.5 Oz
- Type:Powder
- Main Ingredient:Rice starch
- DHA Content:Included
- Probiotics:Yes
- Reflux Reduction:Over 50% in 1 week
Our verdict“This formula is an excellent choice for parents seeking effective reflux management, especially when spit-up is a primary concern.”
Enfamil NeuroPro Gentlease Ready-to-Feed with Smaller Proteins for Easy Digestion, Brain Supporting DHA, HuMO6* Blend, Baby Formula for easing Fussiness, Gas, Spit-up in 24hrs, 2 Fl Oz (6 ct), 4 Pack
This ready-to-feed formula makes a strong case for parents seeking quick relief from fussiness, gas, and spit-up, with results often visible within 24 hours. Compared with Enfamil A.R., which targets reflux more directly, Gentlease emphasizes easy digestion through smaller, broken-down proteins, helping soothe sensitive tummies. It also includes DHA for brain growth and a patented prebiotic blend to promote softer, more regular stools, which is a plus for stool discomfort. However, some parents might find the ready-to-feed format less economical for daily use than powders, and the small 2 oz bottles require frequent purchasing. It’s less tailored to severe reflux but excels at easing general feeding discomfort quickly. This formula suits parents prioritizing rapid comfort and convenience, especially during travel or nighttime feeds.
Pros:- Eases fussiness, crying, gas, and spit-up within 24 hours
- Contains DHA for brain support
- Small, portable bottles ideal for travel
- Includes prebiotics for stool softness and gut health
Cons:- Less economical in the long run compared to powders
- Requires multiple bottles for daily feeding
- Doesn’t specifically target reflux like rice starch formulas
Best for: Parents needing a portable, fast-acting solution for fussiness, gas, and spit-up
Not ideal for: Parents looking for a cost-effective, long-term powder formula primarily for reflux management
- Size:2 fl oz bottles (6 count)
- Type:Ready-to-feed
- DHA:Yes
- Prebiotics:PDX & GOS
- Target Issues:Fussiness, Gas, Spit-up
- Time for Relief:Within 24 hours
Our verdict“This ready-to-feed formula is best suited for parents seeking quick, on-the-go relief from common feeding discomforts.”
Good Start | Dr. Brown’s Gentle Pro, Baby Formula Powder for Sensitive Tummies, Easy Digestion & Softer Poops, Formula with Probiotics, DHA, Allergen Lactose, Milk, Soy,Tree Nuts,Non-GMO,32 OZ, 1 Pack
This formula makes the list for parents seeking a gentle, breastmilk-like option that promotes easier digestion and softer stools. Its high-quality whey protein and advanced hydrolysis make it highly digestible, targeting babies with sensitive stomachs or those prone to constipation. The inclusion of probiotics like B. Lactis adds to its gut-friendly profile, comparable to some of the probiotic-rich formulas like Good Start. However, its larger 32 oz size may be less ideal for parents who prefer smaller quantities or are trying a new formula. While it effectively supports gentle digestion, it might be less suitable for babies with allergies to soy or milk proteins, as it contains both. Overall, this is a strong choice for infants with sensitive digestion needs but less so for those with multiple food allergies.
Pros:- Promotes easy digestion and softer poops
- Contains probiotics for gut health
- Made with high-quality whey protein
- Non-GMO and free from artificial additives
Cons:- Large size may be inconvenient for trial or small feedings
- Contains milk, soy, and tree nuts, which could be problematic for allergies
- Hydrolyzed proteins might cause taste adjustments
Best for: Parents of infants with sensitive stomachs or prone to constipation needing gentle digestion support
Not ideal for: Parents of babies with multiple food allergies or those preferring lactose-free options
- Size:32 oz
- Type:Powder
- Main Protein:Whey
- Probiotics:B. Lactis
- Allergens:Milk, Soy, Tree Nuts
- GMO Status:Non-GMO
Our verdict“This formula is an excellent pick for parents with sensitive-tummy infants who need gentle, digestible nutrition.”
Enfamil NeuroPro Gentlease for easing Fussiness, Crying, Gas, Spit-up in 24 Hrs, Smaller Proteins for Easy Digestion, Brain Supporting DHA, Prebiotic Blend, HuMO6*, Baby Formula, 27.4 Oz Can
This formula is crafted for quick comfort, with clinical evidence showing fussiness, crying, and spit-up can improve within 24 hours. Its focus on smaller, broken-down proteins makes it particularly suitable for sensitive tummies, similar to the Gentlease variant, but with added emphasis on brain support through DHA and a prebiotic blend. Compared to the powder version, this canned formula offers convenience for busy parents while maintaining the same digestive and developmental benefits. A tradeoff is its size—larger than the individual bottles but less portable than ready-to-feed options—and some babies might prefer different textures or flavors. Overall, it makes the most sense for parents who want a reliable, quick-acting formula with added brain and immune support.
Pros:- Reduces fussiness, crying, gas, and spit-up in 24 hours
- Includes DHA for brain development
- Smaller proteins for easier digestion
- Contains prebiotics for stool softness
Cons:- Larger size less convenient for travel
- More expensive than powder alternatives
- Requires preparation time compared to ready-to-feed
Best for: Parents seeking a quick and reliable solution for fussiness, gas, and spit-up with added brain nutrients
Not ideal for: Parents prioritizing ultra-portable or single-serve options for on-the-go feeding
- Size:27.4 oz
- Type:Powder
- DHA Content:Included
- Prebiotics:HuMO6, 2′-FL
- Target Issues:Fussiness, Gas, Spit-up
- Time to Comfort:Within 24 hours
Our verdict“This formula strikes a balance between quick relief and comprehensive brain support, ideal for parents wanting dependable comfort within a day.”
Enfamil Optimum Gentlease Baby Formula, Our Closest Formula to Breast Milk For Fussiness, Crying, Gas & Spit-up, Immune-Supporting Lactoferrin also found in Breast Milk, 19.5 Oz
This formula earns its place by mimicking breast milk closely, especially with the inclusion of lactoferrin, which supports immunity. Its partially hydrolyzed proteins help ease fussiness, crying, and gas, aligning well with parents who want a gentle, nutritious option that’s suitable for daily use. Compared to the other hydrolyzed formulas, its added lactoferrin provides extra immune benefits, making it a smart choice for immune-sensitive babies. The size is manageable for regular feeding routines, but some parents might find it less specialized for severe reflux issues. While it offers comprehensive growth support, it’s less targeted toward quick reflux relief than rice starch-based formulas. Overall, it’s ideal for parents seeking a formula that balances digestion, immunity, and a taste close to breast milk.
Pros:- Closest formula to breast milk available
- Includes lactoferrin for immune support
- Helps reduce fussiness and gas
- Contains DHA and other growth nutrients
Cons:- Less effective for severe reflux than rice starch formulas
- Higher cost compared to standard formulas
- May not be suitable for babies with soy or milk allergies
Best for: Parents wanting a breast-milk-like formula with immune support for fussiness and overall growth
Not ideal for: Parents needing rapid reflux relief or dealing with severe spit-up issues alone
- Size:19.5 Oz
- Type:Powder
- Main Ingredient:Partially Hydrolyzed Proteins
- Key Additive:Lactoferrin
- Includes DHA:Yes
- Target Issue:Fussiness, Gas, General Growth
Our verdict“This formula is best suited for parents wanting a near-breastmilk experience with added immune benefits, but it’s less specialized for reflux.”
Good Start | Dr. Brown’s Soothe Pro, Baby Formula Powder, for Sensitive Tummies, Gas, Fussiness and Spit-Up, Infant Formula with Probiotics, DHA, Non-GMO, 12 Ounces
This formula stands out for its advanced 2-step hydrolysis process, making proteins significantly smaller and easier for sensitive babies to digest, which can be especially beneficial over standard formulas like Enfamil Gentlease. Its inclusion of probiotics and DHA makes it comparable to specialized options like Similac 360 Total Care, but with a focus on reducing fussiness and spit-up from the first bottle. The tradeoff is that it’s more expensive and may be less available in some stores, which could be a hurdle for budget-conscious families. This pick makes the most sense for parents seeking a formula tailored for fussiness, gas, and spit-up, especially if their infant has shown signs of sensitive digestion or intolerance to other formulas.
Pros:- Advanced hydrolysis makes proteins easier to digest
- Includes probiotics and DHA for brain and gut health
- Formulated specifically for fussiness and spit-up
Cons:- Higher price point compared to standard formulas
- Requires mixing and preparation, less convenient than ready-to-feed options
Best for: Parents of newborns with sensitive stomachs who want a formula that supports digestion and reduces fussiness from the start.
Not ideal for: Families on a tight budget or those who prefer a ready-to-feed option, as this powder requires mixing and may be pricier.
- Size:12 ounces
- Protein type:High-quality whey
- Probiotics:L. Reuteri
- Includes DHA:Yes
- Suitable for:0-12 months
- GMO status:Non-GMO
Our verdict“Ideal for parents seeking a highly digestible, gut-friendly formula for sensitive infants, willing to pay a premium for targeted support.”
Similac 360 Total Care Infant Formula, Has 5 HMO Prebiotics, Our Closest Formula to Breast Milk, Baby Formula Powder, 20.6-oz Tub
This formula makes a strong case for mimicking the composition of breast milk, thanks to its five HMO prebiotics, which support immune and digestive health more comprehensively than many competitors. Compared with Enfamil NeuroPro Gentlease, it offers a broader prebiotic profile that can promote softer stools and better gut flora. However, it falls short in addressing specific fussiness or gas issues without added probiotics, making it less targeted for sensitive, colic-prone infants. It’s best suited for parents looking for a formula that emphasizes immune support and gut health, especially if they prioritize ingredients closely aligned with breast milk. The main tradeoff is that it may not provide the immediate digestive relief some parents seek for fussiness or gas.
Pros:- Contains five HMO prebiotics for immune support
- Closest in composition to natural breast milk
- Non-GMO, kosher, and halal certified
Cons:- Less targeted for fussiness or gas compared to specialized formulas
- No added probiotics for reducing colic symptoms
Best for: Parents who want a formula with an ingredient profile closest to breast milk and focus on immune and gut health.
Not ideal for: Parents seeking quick relief from colic symptoms or fussiness, as this formula emphasizes prebiotics over probiotics or hydrolyzed proteins.
- Size:20.6 oz
- Prebiotics:5 HMO prebiotics
- Formulation:Closest to breast milk
- Certifications:Kosher, Halal
- Type:Powder
- Suitable for:0-12 months
Our verdict“Best suited for parents prioritizing immune health and mimicking breast milk, rather than immediate fussiness relief.”
Similac 360 Total Care Sensitive Infant Formula for Fussiness & Gas Due to Lactose Sensitivity, Has 5 HMO Prebiotics, Baby Formula, Ready to Feed, 2-fl-oz Bottle, Pack of 12
This ready-to-feed formula offers convenience plus targeted relief for infants with lactose sensitivity, making it a good choice over powder options like Enfamil Gentlease if ease of use is a priority. Its inclusion of five HMO prebiotics aligns with formulas like Similac 360 Total Care but adds the advantage of being ready to serve, reducing prep time and mess. However, as it’s designed specifically for lactose-sensitive infants, it may not be suitable for babies without lactose issues, and the small 2-fl-oz bottles could become costly over time. This formula suits parents seeking a fuss-free, gentle solution for gas and fussiness related to lactose intolerance, but it’s less flexible if your baby needs a more comprehensive digestion solution.
Pros:- Ready-to-feed for quick and mess-free feeding
- Includes five HMO prebiotics for immune and gut support
- Designed specifically for fussiness and gas from lactose sensitivity
Cons:- Higher cost due to single-serve bottles
- Limited to infants with lactose intolerance
Best for: Parents of infants with diagnosed lactose sensitivity seeking a convenient, ready-to-feed formula for fussiness and gas.
Not ideal for: Parents with non-lactose-sensitive babies or those preferring powder formulas, as this is specialized for a specific intolerance.
- Size:2 fl oz per bottle
- Prebiotics:5 HMO prebiotics
- Formulation:Ready to feed
- Specialty:Lactose sensitive
- Pack size:12 bottles
- Suitable for:0-12 months
Our verdict“Best for lactose-sensitive babies needing an easy, fuss-reducing formula without the hassle of mixing powders.”
MYLICON Infants Gas Relief Drops for Infants and Babies, Dye Free Formula, 1 Fluid Ounce
Mylicon drops distinguish themselves as a fast-acting option for relieving infant gas and discomfort, making them a practical choice over formulas like Enfamil Gentlease when quick relief is needed. Unlike formulas that aim to reduce fussiness over days, Mylicon works within minutes to speed up natural gas expulsion, providing immediate comfort. The key tradeoff is that it only addresses gas, not digestion or long-term colic issues, and must be used frequently, up to 12 times daily. This product is ideal for parents seeking an easy, safe way to soothe their baby during episodes of gas or bloating, but it’s not a substitute for a comprehensive formula solution for ongoing colic or feeding issues.
Pros:- Fast-acting relief from infant gas
- Safe for all infants, including newborns
- No artificial flavors, saccharin, or alcohol
Cons:- Only relieves gas, not addresses underlying digestion or colic
- Requires frequent dosing—up to 12 times daily
Best for: Parents who need quick, effective relief from infant gas and discomfort, especially during episodes of fussiness or bloating.
Not ideal for: Families looking for a nutritional or digestive support formula, as Mylicon only addresses gas temporarily.
- Size:1 fl oz
- Active ingredient:Simethicone
- Dye free:Yes
- Age:All infants
- Dosing:Up to 12 times daily
Our verdict“Ideal for quick, safe relief of infant gas, but not a long-term solution for colic or digestive issues.”
Enfamil NeuroPro Gentlease for easing Fussiness, Crying, Gas, Spit-up in 24 Hrs, Smaller Proteins for Easy Digestion, Brain Supporting DHA, Prebiotic Blend, HuMO6*, Baby Formula, Powder Refill Box, 30.4 Oz
This formula makes a compelling case for families wanting a balance of digestive comfort and brain development, thanks to its smaller, broken-down proteins and added DHA. Compared to Mylicon drops, it offers a long-term nutritional approach rather than immediate gas relief, but it takes about 24 hours to see noticeable improvements in fussiness and spit-up. It also includes a prebiotic blend similar to Similac 360 Total Care, which helps promote softer stools and regularity. A tradeoff is that it’s still a powder requiring preparation, and for some infants with severe colic, immediate relief options like Mylicon may be more suitable initially. This formula suits parents seeking a gentle, nutritious solution that supports both digestion and brain growth over the first month.
Pros:- Smaller, easier-to-digest proteins
- Includes DHA for brain support
- Contains prebiotics for gut health
Cons:- Takes up to 24 hours to show results
- Requires mixing and preparation
Best for: Parents who want a gentle formula that supports both digestion and brain development, with gradual relief from fussiness.
Not ideal for: Families seeking rapid relief from colic symptoms or those preferring ready-to-feed formulas for convenience.
- Size:30.4 oz
- Protein type:Smaller, broken-down
- Includes DHA:Yes
- Prebiotics:Yes
- Target age:0-12 months
- Form:Powder
Our verdict“Ideal for parents seeking a gentle, nutritious formula that gradually eases fussiness and supports development.”
How We Picked
Each formula was evaluated based on its clinical evidence for reducing colic symptoms like fussiness, gas, and spit-up, alongside ingredient quality and digestibility. We prioritized products with proven efficacy, user reviews, and formulations suitable for sensitive tummies. Cost, ease of use, and whether the formula mimics breast milk’s nutritional profile also influenced our rankings. We aimed to highlight options that cater to different needs, from budget-friendly to premium formulas, ensuring a comprehensive guide for parents seeking relief for their newborns.
| formula for colic newborn | Type |
|---|---|
| Enfamil A.R. Infant Formula | Powder |
| Enfamil NeuroPro Gentlease Rea | Ready-to-feed |
| Good Start | Dr. Brown’s Gentl | Powder |
| Enfamil NeuroPro Gentlease for | Powder |
| Enfamil Optimum Gentlease Baby | Powder |
| Good Start | Dr. Brown’s Sooth | — |
| Similac 360 Total Care Infant | Powder |
| Similac 360 Total Care Sensiti | — |
| MYLICON Infants Gas Relief Dro | — |
| Enfamil NeuroPro Gentlease for | — |
Factors to Consider When Choosing Formula For Colic Newborn
When selecting a formula for a colicky newborn, understanding key factors can help you make an informed decision. It’s important to balance ingredients, efficacy, and your baby’s unique sensitivities. Here are some considerations to keep in mind beyond just the formula’s label.Ingredients and Sensitivities
Look for formulas with gentle, easy-to-digest ingredients, especially if your baby has known sensitivities to lactose or milk proteins. Probiotics can support digestion and reduce fussiness, but avoid formulas with unnecessary fillers or allergens. A formula designed for sensitive stomachs often contains fewer potential irritants, which can be beneficial for colicky babies.
Efficacy and Clinical Evidence
Formulas that have clinical backing for reducing reflux, spit-up, and fussiness tend to be more reliable. While some brands tout quick results, check for independent studies or pediatric endorsements that support their claims. Keep in mind that every baby responds differently, so patience is key when trying a new formula.
Formulation Type: Powder vs. Ready-to-Feed
Powder formulas are generally more economical and have a long shelf life, but require preparation, which can be less convenient. Ready-to-feed options offer quick, mess-free use but often come at a higher cost. Consider your daily routine and how much convenience matters versus budget constraints.
Cost and Value
Premium formulas with added probiotics or specialized ingredients tend to cost more but may offer faster or more reliable relief. Conversely, basic formulas can be effective but might require trial and error. Balance your budget with your baby’s response to find the best value for your family.
Consultation and Monitoring
Always consult a pediatrician before switching formulas, especially if your baby has ongoing symptoms. Monitoring your infant’s response and keeping track of changes can help determine whether a formula is truly effective. Sometimes, a combination of dietary adjustments and formula changes yields the best results.
Frequently Asked Questions
How long does it usually take for a colic formula to work?
Most formulas designed to reduce colic symptoms can start showing effects within 24 to 72 hours, but it may take up to a week for full results. Patience is important, as every baby responds differently. Consistency in feeding and monitoring your baby’s reactions will help you determine if the formula is effective.
Can I switch formulas if my baby doesn’t seem to respond?
Yes, switching formulas is common if your baby shows signs of continued discomfort or allergies. However, it’s best to do so gradually—mixing the new formula with the current one over several days—to minimize digestive upset. Always consult your pediatrician before making changes to ensure you choose the right option for your baby’s needs.
Are specialized formulas necessary for colic, or can regular formulas help?
Specialized formulas formulated for colic often contain ingredients like smaller proteins, probiotics, or added reflux-reducing components that standard formulas lack. While some babies respond well to regular formulas, many find relief with these targeted options. Discussing your baby’s symptoms with a healthcare provider can clarify whether a specialized formula is appropriate.
Is ready-to-feed formula worth the extra cost?
Ready-to-feed formulas offer convenience and minimize preparation errors, which can be especially helpful during nighttime feedings. However, they tend to be more expensive per ounce. If your budget allows and convenience is a priority, they can be a worthwhile choice; otherwise, powdered formulas provide a cost-effective alternative with similar benefits.
What ingredients should I avoid in a colic formula?
Avoid formulas with unnecessary additives like artificial preservatives, flavors, or fillers. Also, steer clear of formulas with high levels of lactose if your baby is lactose-sensitive, and be cautious with soy-based options unless recommended by a pediatrician. Reading labels carefully can help you choose a gentle, safe formula that reduces the risk of irritation.
Conclusion
For parents seeking an all-around reliable option, Enfamil A.R. offers proven reflux reduction and broad ingredient support, making it the best overall choice. Those on a tighter budget or seeking quick results might prefer Enfamil NeuroPro Gentlease, thanks to its fast-acting digestion aid. If your baby has sensitivities or allergies, Good Start | Dr. Brown’s Gentle Pro provides a gentle, probiotic-rich option. For first-time parents or those unsure of what their baby needs, starting with a formula that mimics breast milk, like Similac 360 Total Care, can provide peace of mind. Ultimately, matching the formula to your baby’s specific symptoms and your family’s needs will lead to the best results.
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